Must be awakened, pair him up with science/cosmic/tech classes, use parry to apply debuffs. See his "Leadership" signature ability for more details.

apply bleeds, poisons as usual. beware of immune champs. neurotoxins do not count as debuffs but do damage if you already applied 3 bleed/poison debuffs.

build up Shock charges by holding block, release them with a well timed block, consider using Proxima Midnight synergy

SP1 can stack incinerate debuffs and the native power gain ensures you can access a lot of these. Armor break of SP2 also counts as a debuff.

You can easily stack Incinerate debuffs. The higher the temperature the longer these debuffs last. Warning: don't activate the pre-fight ability as Nova Flames are passive and thus not considered as debuffs. Also beware of incinerate immune opponents.

Easy stacking of bleed debuffs. Recommended: Landing a Heavy attack inflicts 3 stacks of bleed for 12s. Beware of bleed immune opponents.

Easy access to bleed debuffs. Well timed blocks inflict 3 stacks of bleed debuffs. Beware of bleed immune opponents.

Landing a Heavy or a SP1 inflicts 3 stacks of debuffs (either bleed, poison or incinerate, depending on the Curse) and these can be even inflicted remotely, with no contact, while the opponent is blocking.

Automatic and recurrent infliction of infinite debuffs. SP1 also inflicts one additional infinite debuff. You will not do damage at the beginning of the fight until you reach the 3 debuff stack level. And if awakened you may face the same situation again when Fear of the Void activates and converts all debuffs into passives.