The Defender takes 100% less damage while they have less than 3 Debuffs applied to them.
These Debuffs can be of the same type.
Captain America (Infinity War)
Must be awakened, pair him up with science/cosmic/tech classes, use parry to apply debuffs. See his "Leadership" signature ability for more details.
apply bleeds, poisons as usual. beware of immune champs. neurotoxins do not count as debuffs.
build up Shock charges by holding block, release them with a well timed block, consider using Proxima Midnight synergy